Therapeutic Hyperthermia Associated with Improved Survival in Afebrile Critically Ill Patients with Sepsis

Therapeutic Hyperthermia Associated with Improved Survival in Afebrile Critically Ill Patients with Sepsis

Participants randomized to external forced-air warming did not have a difference in HLA-DR expression or IFN-γ production. In this pilot study, however, 28-day mortality was lower in the intervention group. Future research... read more

Approach to the Critically Ill Poisoned Patient

Approach to the Critically Ill Poisoned Patient

Toxicology histories are notoriously unreliable. Any available medical records, especially medication lists. Timing & amount of ingestions. Immediate vs. sustained-release formulations. Consider inquiring specifically... read more

The Effect of Early Sedation With Dexmedetomidine on Body Temperature in Critically Ill Patients

The Effect of Early Sedation With Dexmedetomidine on Body Temperature in Critically Ill Patients

Previous case series reported an association between dexmedetomidine use and hyperthermia. Temperature data have not been systematically reported in previous randomized controlled trials evaluating dexmedetomidine. Our... read more

From Russia with Love – “Sputnik V” COVID-19 Vaccine Generated an Immune Response

From Russia with Love – “Sputnik V” COVID-19 Vaccine Generated an Immune Response

Between June 18 and Aug 3, 2020, Ministry of Health of the Russian Federation enrolled 76 participants to the two studies (38 in each study). In each study, 9 volunteers received rAd26-S in Phase 1, nine received rAd5-S in... read more

Is Tranexamic Acid Going to CRASH the Management of TBI?

Is Tranexamic Acid Going to CRASH the Management of TBI?

In the recent CRASH-3 randomized trial, early administration of tranexamic acid (TXA) was associated with a non-significant reduction of head injury-related 28-day mortality in patients with isolated traumatic brain injury... read more

Pericardiocentesis During Cardiopulmonary Resuscitation

Pericardiocentesis During Cardiopulmonary Resuscitation

In this video, Dr. Traci Wolbrink reviews the procedural steps to performing Pericardiocentesis as well as reviewing indications, contraindications and risk factors for patients experiencing pericardial effusion. ... read more

Evaluation of Medetomidine-ketamine and Atipamezole for Reversible Anesthesia of Free-ranging Gray Wolves

Evaluation of Medetomidine-ketamine and Atipamezole for Reversible Anesthesia of Free-ranging Gray Wolves

Twenty-eight anesthetic events were carried out on 24 free-ranging Scandinavian gray wolves (Canis lupus) by darting from a helicopter with 5 mg medetomidine and 250 mg ketamine during winter in 2002 and 2003. Mean±SD doses... read more

Is Fever the Normal Temperature of Sepsis

Is Fever the Normal Temperature of Sepsis

We know that hypothermia in sepsis is associated with increased mortality but other than that we tend to see fever in sepsis as something bad. We tend to perceive sepsis patients as more sick the more the temperature is elevated.... read more

Dexmedetomidine-Associated Hyperthermia

Dexmedetomidine-Associated Hyperthermia

Dexmedetomidine-associated hyperthermia: a retrospective cohort study of intensive care unit admissions between 2009 and 2016. Dexmedetomidine-associated hyperthermia has not been previously studied. Analysis is warranted... read more

Whole Body Hyperthermia Appeared to Reduce Depression Symptoms

Whole Body Hyperthermia Appeared to Reduce Depression Symptoms

Whole-body hyperthermia holds promise as a safe, rapid-acting, antidepressant modality with a prolonged therapeutic benefit. Results from the current study suggest that WBH holds promise as a safe, rapid-acting, antidepressant... read more