In this study, we found that overall, in-hospital mortality rates increase with each 0.5 °C/h decrease in rewarming rate (RR). However, judging from the results of subgroup analyses, the safest RR might differ according... read more

After completing her medical training in New York, Susan Levenstein set off for a one year adventure in Rome. Forty years later, she is still practicing medicine in the Eternal City. In Dottoressa: An American Doctor in Rome... read more

Among more than 160,000 patients admitted to University of North Carolina hospitals during a recent 5-year period, non-device-associated, or ND, pneumonia was implicated in three of every four nosocomial pneumonia cases,... read more

The purpose of this study was to evaluate survival to hospital discharge for patients on venovenous extracorporeal membrane oxygenation (VV ECMO) when stratified by age. We performed a retrospective study at single, academic,... read more

As the American born daughter of immigrants, Dr. Sunita Puri knew from a young age that the gulf between her parents’ experiences and her own was impossible to bridge, save for two elements: medicine and spirituality.... read more

Tramadol is an opioid, but it does not bind directly to opioid receptors (or it binds so weakly that it might as well not bind at all). Its opioid action is the result of the metabolite O-desmethyltramadol, which means it... read more

Major complications fall by 12%, time on a ventilator declines by 13% among children in the cardiac ICU at PC4 hospitals As a pediatric cardiology fellow nearly a decade ago, Michael Gaies remembers asking hospital colleagues... read more

This issue of Critical Care Clinics, edited by Dr. Kianoush Kashani in collaboration with Consulting Editor Dr. John Kellum, is focused on Intensive Care Unit Telemedicine. Topics in this issue include: ICU telemedicine program... read more

In a propensity score–matched cohort, patients with recurrent Clostridioides difficile Infection (CDI) treated with fecal microbiota transplantation (FMT) were less likely to develop primary bloodstream infection (BSI).... read more

Mayo Clinic Critical and Neurocritical Care Board Review is an all-inclusive review of the pathophysiology and care of the neurocritically ill and critically ill patient. The book reviews the core major critical care and... read more

Despite having the tools and techniques for tracheal intubation for > 4000 years, and performing oral intubation with positive pressure mechanical ventilation for > 50 years, only recently has attention focused on... read more

Right ventricular dysfunction (RVD) is an indicator of poor prognosis in normotensive patients with acute pulmonary embolism (APE). The aim of this study was to compare right ventricular (RV)/left ventricular (LV) ratio measured... read more

In children on mechanical ventilation, early tracheostomy may improve important medical outcomes. However, our data demonstrate the urgent need for high-quality, randomized controlled trials in the pediatric population. Data... read more

Pediatric intensive units traditionally have had a culture where critically ill children are intubated and mechanically ventilated, immobilized, and highly sedated. This practice is primarily driven by a focus on safety and... read more

Centralized pain syndromes are associated with changes within the central nervous system that amplify peripheral input and/or generate the perception of pain in the absence of a noxious stimulus. Examples of idiopathic functional... read more

In-line filtration with finer 0.2 and 1.2 μm filters may be associated with less organ dysfunction and less inflammation in critically ill adult patients. Comparing fine filter vs control filter cohort, respiratory dysfunction,... read more

The Food and Drug Administration on Monday approved a once-daily pill for sickle cell disease that works in an entirely new way — by boosting hemoglobin, the oxygen-carrying molecule found in red blood cells. The novel... read more

Adult patients undergoing noncardiac surgery demonstrate varying associations with distinct levels of hypotension when stratified by preoperative risk factors. Specific levels of absolute hypotension, but not relative hypotension,... read more

The only comprehensive source of information on this frequently misdiagnosed problem, with information critical for physicians, ER and ICU doctors, and psychiatrists. An under-recognized condition that can potentially cause... read more

Nonconvulsive status epilepticus (NCSE) is characterized by persistent change in mental status from baseline lasting more than 5 minutes, generally with epileptiform activity seen on EEG monitoring and subtle or no motor... read more