Predicting Readmission or Death After Discharge From the ICU with Machine Learning

Predicting Readmission or Death After Discharge From the ICU with Machine Learning

In this era of expanding availability of ML models, external validation and retraining are key steps to consider before applying machine learning (ML) models to new settings. Clinicians and decision-makers should take... read more

Multiple Organ Dysfunction in Older Major Trauma Critical Care Patients

Multiple Organ Dysfunction in Older Major Trauma Critical Care Patients

Frailty rather than chronological age appears to drive multiple organ dysfunction syndrome (MODS) development, recovery, and outcome in older cohorts. Early identification of frailty after trauma may help to predict MODS... read more

ARDS Readmissions: A nationwide Cross-sectional Analysis of Epidemiology

ARDS Readmissions: A nationwide Cross-sectional Analysis of Epidemiology

Thirty-day readmission occurred in 18.4% of patients with acute respiratory distress syndrome (ARDS) in this sample, and early readmission is strongly associated with increased mortality compared to late readmission. Further... read more

Association Between Dexamethasone Treatment for COVID-19 Patients and Rates of Hospital Readmission and Mortality

Association Between Dexamethasone Treatment for COVID-19 Patients and Rates of Hospital Readmission and Mortality

Current guidelines recommend use of dexamethasone, 6 mg/d, up to 10 days or until discharge for patients hospitalized with COVID-19. Whether patients who received less than 10 days of corticosteroids during hospitalization... read more

Impact of Frailty on Persistent Critical Illness

Impact of Frailty on Persistent Critical Illness

Compared to patients without frailty, those with frailty have a higher chance of developing and dying from Persistent Critical Illness (PerCI). Moreover the importance of frailty as a predictor of mortality increases with... read more

Association Between Incident Delirium Treatment with Haloperidol and Mortality in Critically Ill Adults

Association Between Incident Delirium Treatment with Haloperidol and Mortality in Critically Ill Adults

Treatment of incident delirium and its symptoms with haloperidol may be associated with a dose-dependent improvement in survival. Future randomized trials need to confirm these results. Patients were evaluated tid for... read more

Anticoagulation in COVID-19

Anticoagulation in COVID-19

Thrombotic complications (arterial and venous) are common in patients admitted to hospital with COVID-19 and are an independent predictor of poor outcome. Microvascular thrombi also contribute to organ dysfunction, including... read more

Prognostic and Predictive Biomarkers in COVID-19 Patients Treated with Tocilizumab

Prognostic and Predictive Biomarkers in COVID-19 Patients Treated with Tocilizumab

Multiple biomarkers prognostic for clinical outcomes were confirmed in COVACTA. Ferritin was identified as a predictive biomarker for the effects of tocilizumab in the COVACTA patient population; high ferritin levels were... read more

Rivaroxaban vs. No Anticoagulation for Post-discharge Thromboprophylaxis After COVID-19 Hospitalisation

Rivaroxaban vs. No Anticoagulation for Post-discharge Thromboprophylaxis After COVID-19 Hospitalisation

In patients at high risk discharged after hospitalisation due to COVID-19, thromboprophylaxis with rivaroxaban 10 mg/day for 35 days improved clinical outcomes compared with no extended thromboprophylaxis. From Oct 8,... read more

Effectiveness of Therapeutic Heparin vs. Prophylactic Heparin on COVID-19 Patients

Effectiveness of Therapeutic Heparin vs. Prophylactic Heparin on COVID-19 Patients

In moderately ill patients with covid-19 and increased D-dimer levels admitted to hospital wards, therapeutic heparin was not significantly associated with a reduction in the primary outcome but the odds of death at 28 days... read more

Dynamic Delirium Severity Trajectories and Healthcare Utilization

Dynamic Delirium Severity Trajectories and Healthcare Utilization

This secondary analysis did not identify a significant relationship between delirium severity trajectories and healthcare utilization or mortality within 2 years of hospital discharge. The overall sample (n = 431) had... read more

Impact on Mental, Physical and Cognitive functioning of a Critical care sTay during the COVID-19 pandemic

Impact on Mental, Physical and Cognitive functioning of a Critical care sTay during the COVID-19 pandemic

The ongoing pandemic could affect the duration, variety and severity of the mental, physical, and cognitive impairments intensive care unit (ICU) survivors and their families frequently present. We aim to determine the impact... read more

Changes in Barriers to Implementing Early Mobilization in the ICU

Changes in Barriers to Implementing Early Mobilization in the ICU

This study was undertaken to investigate the rate of mobilization, defined as a rehabilitation level of sitting on the edge of a bed or higher, and its association with changes in barriers in the intensive care unit (ICU).... read more

Pre-hospital suPAR, Lactate and CRP Measurements for Decision-making

Pre-hospital suPAR, Lactate and CRP Measurements for Decision-making

Pre-hospital suPAR measurements alone or combined with C-reactive protein (CRP) and/or lactate measurements could not predict the ED discharge or hospital admission of 109 non-urgent EMS patients with non-specific chief complaints... read more