Introduction to Hemodynamics

Introduction to Hemodynamics

This book presents a bibliographical work on the modeling of blood dynamics. The first chapter describes the anatomy of the cardiovascular system and the functioning of the blood circulation. The second chapter is devoted... read more

High Speed Blood Flow Measurements Enabled by LW-iDCS

High Speed Blood Flow Measurements Enabled by LW-iDCS

In this work we have demonstrated the development of long wavelength, interferometric diffuse correlation spectroscopy. Using a fiber optic probe with collocated detection fibers, we were able to directly compare measured... read more

No Benefits For Using 4-Factor Prothrombin Complex Concentrate (4F-PCC) in Trauma Patients

No Benefits For Using 4-Factor Prothrombin Complex Concentrate (4F-PCC) in Trauma Patients

Early administration of 4-factor prothrombin complex concentrate (4F-PCC) was of no benefit to patients with trauma at risk of massive transfusion, the randomized PROCOAG trial from France showed. Among over 300 patients... read more

Blood-Pressure Targets in Comatose Survivors of Cardiac Arrest

Blood-Pressure Targets in Comatose Survivors of Cardiac Arrest

Targeting a mean arterial blood pressure of 77 mm Hg or 63 mm Hg in patients who had been resuscitated from cardiac arrest did not result in significantly different percentages of patients dying or having severe disability... read more

Trauma-induced Coagulopathy

Trauma-induced Coagulopathy

Trauma is a major cause of mortality worldwide, and bleeding is the leading preventable cause of death. About one-quarter of patients with severe trauma develop a clotting disorder termed trauma-induced coagulopathy (TIC)... read more

Economical provision of blood components for critical patient transport across a large geographic area

Economical provision of blood components for critical patient transport across a large geographic area

With appropriate attention to detail, it is possible to provide life-saving blood components to aeromedical transport services across a large geographic area with efficient blood component usage, minimal blood wastage, and... read more

Combined Platelet and Erythrocyte Salvage: Evaluation of a New Filtration-based Autotransfusion Device

Combined Platelet and Erythrocyte Salvage: Evaluation of a New Filtration-based Autotransfusion Device

This study demonstrated the performance of the SAME device. Platelets and red blood cells were salvaged without significant impact on cell integrity and function. In the meantime, leukocytes were not activated, and the washing... read more

COVID-19: Convalescent Plasma vs. Standard Plasma

COVID-19: Convalescent Plasma vs. Standard Plasma

Administration of convalescent plasma to hospitalized patients with coronavirus disease 2019 infection increased antibodies to severe acute respiratory syndrome coronavirus disease 2 but was not associated with improved outcome. Enrollment... read more

Normalization of blood clotting characteristics using prothrombin complex concentrate, fibrinogen and FXIII in an albumin based fluid

Normalization of blood clotting characteristics using prothrombin complex concentrate, fibrinogen and FXIII in an albumin based fluid

Combinations of coagulation factor concentrates suspended in albumin solutions can restore thromboelastometry parameters in the absence of plasma. This kind of artificial colloid fluids with coagulation-restoring characteristics... read more

The Blood-Clot Problem Is Multiplying

The Blood-Clot Problem Is Multiplying

For weeks, Americans looked on as other countries grappled with case reports of rare, sometimes fatal blood abnormalities among those who had received the AstraZeneca vaccine against COVID-19. That vaccine has not yet... read more

Early Hemostatic Management of Disseminated Intravascular Coagulopathy

Early Hemostatic Management of Disseminated Intravascular Coagulopathy

Inflammation and coagulation pathobiology play a significant role in the development of multiorgan failure occurring with sepsis. Inflammation induced by an infection can lead to endothelial injury, which subsequently... read more

COVID-19 Blood Plasma Trial Finds No Benefit in Severely Ill Patients

COVID-19 Blood Plasma Trial Finds No Benefit in Severely Ill Patients

An international trial testing convalescent blood plasma on COVID-19 patients with moderate and severe illness has halted enrolment of severely ill COVID-19 patients requiring intensive care after it found no benefit. The... read more

NIH ACTIV trial of blood thinners pauses enrollment of critically ill COVID-19 patients

NIH ACTIV trial of blood thinners pauses enrollment of critically ill COVID-19 patients

Three clinical trial platforms working together to test the effects of full doses of anticoagulants (blood thinners) in COVID-19 patients have paused enrollment for one group of patients. Among critically ill COVID-19... read more

Pulse Oximeter Devices Have Higher Error Rate in Black Patients

Pulse Oximeter Devices Have Higher Error Rate in Black Patients

A study showed that the devices, which measure oxygen levels in the blood, were three times more likely to give misleading readings among African-American patients. Pulse oximeters are one of the most commonly used tools... read more