In this single-center case series of 138 hospitalized patients with confirmed 2019 novel coronavirus (2019-nCoV)–infected pneumonia (NCIP) in Wuhan, China, presumed hospital-related transmission of 2019-nCoV was suspected... read more

SARS was the first new plague of the twenty-first century. Within months, it spread worldwide from its “birthplace” in Guangdong Province, China, affecting over 8,000 people in 25 countries and territories across... read more

Globally, there were an estimated 60.2 million cases of sepsis in 1990 and 48.9 million cases of sepsis in 2017. This change represents a decrease of 18.8%. Of all incident cases of sepsis in 2017, 33.1 million occurred in... read more

In response to the 2019 Novel Coronavirus (2019-nCoV) outbreak, the federal government is taking steps to protect the country. Within the U.S. Department of Health and Human Services, the Office of the Assistant Secretary... read more

This book tells their communal story, the story of medical history, entomology, vector-borne diseases, virology, epidemiology and related fascinating but little recognized disciplines Interweaving his own personal stories... read more

Centers for Disease Control (CDC), published methodology for 2019-Novel Coronavirus (2019-nCoV) testing and is currently in the process of applying for an emergency waiver to allow medical-testing facilities to perform these... read more

This clinical casebook provides a comprehensive yet concise state-of-the-art review of adult critical care medicine. Presented in a case-based format, each case focuses on a scenario commonly encountered with an adult patient... read more

The management of the patient with lung fibrosis in the ICU is a challenge for the intensivist. The lack of studies defining the mechanical ventilation strategy, and the different underlying etiologies, make it difficult... read more

Portions of the current WHO guidelines regarding fluid management are dangerously misguided. The first two recommendations suggest limiting fluid administration in patients with ARDS and patients who aren’t shocked,... read more

Our bodies are very good at fighting infection. The immune system reacts and attacks bacteria and viruses that make us sick. But sometimes the immune reaction is so strong that it damages the body. This is called a septic... read more

In general, randomized clinical trials in CS are difficult to perform and only three randomized trials adequately powered to detect differences in clinical outcomes achieved completion of the required number of patients.... read more

Fleisher & Ludwig’s Textbook of Pediatric Emergency Medicine has long been acknowledged as the indispensable comprehensive clinical reference on diagnosing and managing emergent health issues in children. Now,... read more

The expiratory muscles are the “neglected component” of the respiratory muscle pump. Rather as the heart does not comprise only a left ventricle, but also a right one, the respiratory muscle pump is much more... read more

In a population of critically ill patients undergoing goal-directed ultrasound examinations, elevating head-of-bed (HOB) to 30° did not significantly alter inferior vena cava (IVC) measurements or CI. At 45°, however, IVCmax... read more

With a focus on evidence-based, state-of-the-art information throughout, the eighth edition of Irwin and Rippe’s Intensive Care Medicine offers authoritative guidance to the wide variety of specialty physicians and... read more

Prone positioning (PP) during veno-venous ECMO is feasible, but its physiological effects have never been thoroughly evaluated. Our objectives were to describe, through electrical impedance tomography (EIT), the impact of... read more

Studies examining the use of tranexamic acid (TXA) inescapably seem to pit our rigorous methodological demons against our practical clinical angels. The CRASH-2 trial randomized 20,211 adult trauma patients presenting to... read more

Continuous renal replacement therapy (CRRT) is associated with reduced ammonia concentrations in acute liver failure patients. This effect is related to greater cumulative dose. These findings suggest that continuous renal... read more

Using the KDIGO criteria for both serum creatinine and urine output to define acute kidney injury (AKI), 39.8% of patients between the ages of 16–25 met AKI criteria during admission to an adult tertiary care center, indicating... read more

Health coaching may provide a scalable model that can improve care for people living with chronic obstructive pulmonary disease (COPD). Baseline adherence and inhaler technique were uniformly poor and did not differ by study... read more

Reduced glucose variability is highly correlated with in-patient survival and long-term mortality in subarachnoid hemorrhage (aSAH) patients. This finding was observed in the non-diabetic and well-controlled diabetic patients,... read more

The authors concluded that high suPAR levels were associated with Acute Kidney Injury (AKI) in various clinical and experimental contexts. This cohort study reports that suPAR was associated with subsequent AKI in several... read more