Damage Control Resuscitation: Identification and Treatment of Life-Threatening Hemorrhage

Damage Control Resuscitation: Identification and Treatment of Life-Threatening Hemorrhage

This book provides a comprehensive overview of damage control resuscitation (DCR), an evidence-based approach to the resuscitation of patients with severe life-threatening hemorrhage (LTH). It focuses on both civilian... read more

TXA Should be Urgently and Broadly Adopted for Brain Bleeds

TXA Should be Urgently and Broadly Adopted for Brain Bleeds

Everything looked better with tranexamic acid (TXA), and none of it was statistically significant. True, in a subgroup analysis of patients who actually had a head bleed on imaging—which, gee whiz, seems like an important... read more

Artesunate Treatment in Severely Injured Patients with Traumatic Hemorrhage

Artesunate Treatment in Severely Injured Patients with Traumatic Hemorrhage

In this study of critically injured trauma patients with major hemorrhage, artesunate did not improve organ dysfunction and was potentially associated with an increased VTE risk. Future studies that focus on immune responses... read more

Early Control of Elevated Blood Pressure – INTERACT3

Early Control of Elevated Blood Pressure – INTERACT3

Early control of elevated blood pressure is the most promising treatment for acute intracerebral hemorrhage. We aimed to establish whether implementing a goal-directed care bundle incorporating protocols for early intensive... read more

Disseminated Intravascular Coagulation in COVID-19 Setting

Disseminated Intravascular Coagulation in COVID-19 Setting

Disseminated intravascular coagulation (DIC) is an acquired syndrome that can lead to catastrophic thrombosis and hemorrhage. In DIC, an uncontrolled release of pro-inflammatory mediators activates tissue factor-dependent... read more

Traumatic Hemorrhage and Chain of Survival

Traumatic Hemorrhage and Chain of Survival

Trauma is the number one cause of death among Americans between the ages of 1 and 46 years, costing more than $670 billion a year. Following death related to central nervous system injury, hemorrhage accounts for the majority... read more

Marburg Virus Disease Outbreaks in Equatorial Guinea and Tanzania

Marburg Virus Disease Outbreaks in Equatorial Guinea and Tanzania

The Centers for Disease Control and Prevention (CDC) is issuing this Health Alert Network (HAN) Health Advisory to inform clinicians and public health departments in the United States about two confirmed outbreaks of Marburg... read more

A Young Doctor’s Perspective Was Forever Changed by ICU Experience

A Young Doctor’s Perspective Was Forever Changed by ICU Experience

A healthy 30-year-old doctor had an unexpected medical emergency while preparing for a procedure, which led to the discovery of a small hemorrhage in her dorsal brainstem. She was transferred to the neuro ICU and experienced... read more

Intracranial Pressure: Current Perspectives on Physiology and Monitoring

Intracranial Pressure: Current Perspectives on Physiology and Monitoring

Intracranial pressure (ICP) monitoring is now viewed as integral to the clinical care of many life-threatening brain insults, such as severe traumatic brain injury, subarachnoid hemorrhage, and malignant stroke. It serves... read more

Algorithm to Predict Thromboembolism in COVID-19 Patients

Algorithm to Predict Thromboembolism in COVID-19 Patients

Patients with COVID-19 are at increased risk for thrombosis and might be stratified on admission based on lower Pao2/FiO2 ratio, higher D-dimer levels and history of major hemorrhages. 64 thromboses were recorded in 54... read more

Advanced Bleeding Control in Combat Casualty Care

Advanced Bleeding Control in Combat Casualty Care

Consensus was reached on the contents of a standard bleeding control toolbox, where it should be available, providers and training requirements, international registries and guidelines, and potential indications for REBOA... read more

Bleeding and Thrombotic Events in Patients with Severe COVID‑19 on ECMO

Bleeding and Thrombotic Events in Patients with Severe COVID‑19 on ECMO

In a nationwide cohort of COVID‑19 patients supported by extracorporeal membrane oxygenation (ECMO), bleeding incidence was high and associated with mortality. Intracranial hemorrhage incidence was higher than reported... read more

Arterial Carbon Dioxide and Acute Brain Injury in VA-ECMO

Arterial Carbon Dioxide and Acute Brain Injury in VA-ECMO

Acute brain injury (ABI) occurs frequently in patients receiving venoarterial extracorporeal membrane oxygenation (VA-ECMO). We examined the association between peri-cannulation arterial carbon dioxide tension (PaCO2) and... read more

General Anesthesia vs. Sedation Using Hemodynamic Control During Intraarterial Treatment for Stroke

General Anesthesia vs. Sedation Using Hemodynamic Control During Intraarterial Treatment for Stroke

The functional outcomes 3 months after endovascular treatment for stroke were similar with general anesthesia and sedation. Our results, therefore, suggest that clinicians can use either approach. Of 351 randomized patients,... read more