Although the paper is not even officially published yet, everyone has already heard the results. We have our first treatment that appears to reduce mortality in COVID-19 patients. For a week or so, we only had press release,... read more

The book we need NOW to avoid a social recession, Murthy’s prescient message is about the importance of human connection, the hidden impact of loneliness on our health, and the social power of community. Humans are social... read more

These data demonstrate that trauma-induced immunosuppression is characterized by an interleukin-10-dependent elimination of dendritic cell by natural killer cells and that hydrocortisone improves outcome by limiting this... read more

Among patients with severe or life-threatening COVID-19, convalescent plasma therapy added to standard treatment, compared with standard treatment alone, did not result in a statistically significant improvement in time to... read more

The sensitivity of antibody tests is too low in the first week since symptom onset to have a primary role for the diagnosis of COVID-19, but they may still have a role complementing other testing in individuals presenting... read more

In spring, NHS staff responded to the looming COVID-19 pandemic with an impressive level of strategic planning. As operating theatres closed and ICU beds were created, anaesthetists and intensivists faced new challenges on... read more

This is the premier evidence-based textbook in critical care medicine. The Third Edition features updated and revised chapters, numerous new references, streamlined content, and new chapters on key topics such as the new... read more

Recent reports from China, Italy, and the US indicate that there is a 25-37% incidence of AKI among critically ill COVID-19 patients (Singh 2020, Hirsch et al. 2020). In a study of 5,449 hospitalized COVID-19 patients, acute... read more

Resuming procedural sedation services for elective procedures during the COVID-19 pandemic requires unique considerations to ensure safety for patients and providers. Guidelines for resuming these procedures, including timing,... read more

This text provides a concise, yet comprehensive overview of telemedicine in the ICU. The first part of the book reviews common issues faced by practitioners and hospital administrators in implementing and managing tele-ICU... read more

Difficult bag-mask ventilation is reported in approximately one in 10 PICU patients undergoing tracheal intubation. Given its association with adverse procedure–related events and oxygen desaturation, future study is warranted... read more

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused more than 5 million cases of coronavirus disease (COVID-19) worldwide and 345,000 deaths as of 25 May 2020. Based on accumulating international experience... read more

It is not unreasonable to say the COVID-19 pandemic caught most of us by surprise. We did not know how infectious the Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) virus leading to COVID-19 disease was, nor... read more

More than two months later, that piece of paper still lies on her coffee table with four letters on it: “E-C-M-O.” Irena Veronese had never heard that acronym before, but when it was first mentioned to her, it... read more

The COVID-19 pandemic, tests, treatments, and outlook, continue to be front and center in the news, along with other urgent issues taking place across the country. Viral sepsis is the number one complication related to COVID-19,... read more

Controversies and trends have always been present in nephrology. Since its inception and throughout its development, renal replacement therapy has been shrouded in uncertainty, even as it advances, and it has always been... read more

This systematic review summarizes all premorbid, illness-related, and ICU-related factors associated with sleep disruption in the ICU. These findings will inform sleep promotion efforts in the ICU and guide further research... read more