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RECENT COVID-19 NEWS

 
Efficacy and Safety of a Paired Sedation and Ventilator Weaning

 

Efficacy and Safety of a Paired Sedation and Ventilator Weaning

The purpose of this study is to determine the impact of a new RN/RRT (Registered Nurse/Registered Respiratory Therapist) directed 2-step protocol to wean patients off of a ventilator. This protocol involves daily attempts... read more

 
 
Principles of Critical Care

 

Principles of Critical Care

Quickly and accurately diagnose and treat the critically ill patient with guidance from the field’s definitive text. Considered the field’s definitive text, Principles of Critical Care offers unmatched coverage... read more

 
 
COVID-19 Drug Treatments: Living Systematic Review and Network Meta-analysis

 

COVID-19 Drug Treatments: Living Systematic Review and Network Meta-analysis

Glucocorticoids probably reduce mortality and mechanical ventilation in patients with COVID-19 compared with standard care. The effectiveness of most interventions is uncertain because most of the randomised controlled trials... read more

 
 
Respiratory Support in Patients with COVID-19

 

Respiratory Support in Patients with COVID-19

Non-invasive respiratory support could be useful in treating COVID-19-related acute respiratory failure (ARF). A rational use of different techniques (oxygen therapy, CPAP, NIV or HFOT) by a trained pulmonologist could allow... read more

 

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NICE COVID-19 Rapid Guideline

 

NICE COVID-19 Rapid Guideline

The purpose of this guideline is to help healthcare professionals deliver efficient planned care while minimising the risk of COVID-19 in the context of increasing or decreasing local prevalence. It also aims to help patients... read more

 
 
Critical Care Medicine: Principles of Diagnosis and Management in the Adult

 

Critical Care Medicine: Principles of Diagnosis and Management in the Adult

Now completely revised to bring you up to date with the latest advances in the field, Critical Care Medicine: Principles of Diagnosis and Management in the Adult, 5th Edition, delivers expert, practical guidance on virtually... read more

 
 
Working in ICU is like Flying a Plane: The Secret World of Intensive Care

 

Working in ICU is like Flying a Plane: The Secret World of Intensive Care

Stepping on to the ICU during this period was like entering another world. In a way intensive care has always seemed like a place removed from life outside said Mike Brunner, an intensive care doctor at Northwick Park hospital... read more

 
 
Epidemiology of Invasive Pulmonary Aspergillosis Among COVID-19 Intubated Patients

 

Epidemiology of Invasive Pulmonary Aspergillosis Among COVID-19 Intubated Patients

We found a high incidence of CAPA among critically ill COVID-19 patients and that its occurrence seems to change the natural history of disease. A total of 108 patients were enrolled. Prospective, multicentre study on adult... read more

 
 
Longitudinal Analyses Reveal Immunological Misfiring in Severe COVID-19

 

Longitudinal Analyses Reveal Immunological Misfiring in Severe COVID-19

Recent studies have provided insights into the pathogenesis of COVID-19. Yet, longitudinal immunological correlates of disease outcome remain unclear. Here, we serially analysed immune responses in 113 COVID-19 patients with... read more

 
 
COPD: Heterogeneity and Personalized Treatment

 

COPD: Heterogeneity and Personalized Treatment

This book explains how analysis of the heterogeneity of chronic obstructive pulmonary disease (COPD) enhances understanding of the condition and leads to improved, personalized treatment. State of the art knowledge is presented... read more

 
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Thrombosis and Bleeding in ECMO without Anticoagulation

 

Thrombosis and Bleeding in ECMO without Anticoagulation

Extracorporeal membrane oxygenation (ECMO) causes both thrombosis and bleeding. Major society guidelines recommend continuous, systemic anticoagulation to prevent thrombosis of the ECMO circuit, though this may be undesirable... read more

 
 
Aerosol and Surface Distribution of SARs-CoV-2 in Hospital Wards

 

Aerosol and Surface Distribution of SARs-CoV-2 in Hospital Wards

In a hospital treating COVID-19 patients, SARS-CoV-2 RNA was found widely distributed in surface and air samples. Contamination was greater in intensive care units (54/124 samples) than general wards (9/114 samples). A 100%... read more

 
 
Cost Analysis of Adjunctive Hydrocortisone Therapy for Septic Shock

 

Cost Analysis of Adjunctive Hydrocortisone Therapy for Septic Shock

Using adjunctive hydrocortisone therapy yields a significant monetized benefit based on inputs from the Adjunctive Corticosteroid Treatment in Critically Ill Patients with Septic Shock and Activated Protein C and Corticosteroids... read more

 
 
Respiratory Strategies for Patients with Suspected or Proven COVID-19 Respiratory Failure

 

Respiratory Strategies for Patients with Suspected or Proven COVID-19 Respiratory Failure

The trial objective is to determine if Continuous Positive Airway Pressure (CPAP) or High-Flow Nasal Oxygen (HFNO) is clinically effective compared to standard oxygen therapy in patients with confirmed or suspected COVID-19.... read more

 
 
SARS-CoV-2-reactive T Cells in Healthy Donors and Patients with COVID-19

 

SARS-CoV-2-reactive T Cells in Healthy Donors and Patients with COVID-19

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the rapidly unfolding coronavirus disease 2019 (COVID-19) pandemic. Clinical manifestations of COVID-19 vary, ranging from asymptomatic infection to... read more

 
 
Development of Persistent Respiratory Morbidity in Previously Healthy Children After ARF

 

Development of Persistent Respiratory Morbidity in Previously Healthy Children After ARF

Persistent respiratory morbidity develops in up to potentially 44% of previously healthy children less than or equal to 24 months old at follow-up after acute respiratory failure (ARF) requiring mechanical ventilation. This... read more

 
 
Ground-breaking Research – Venous Thrombosis is Back in Business

 

Ground-breaking Research – Venous Thrombosis is Back in Business

The primary efficacy outcome was the development of a major venous thromboembolic event such as symptomatic distal or proximal deep-vein thrombosis, asymptomatic deep vein thrombosis, pulmonary embolism or venous thromboembolism–related... read more

 
 
Inhaled Pulmonary Vasodilators

 

Inhaled Pulmonary Vasodilators

Confusion between inhaled versus intravenous routes for pulmonary vasodilators. For optimal clinical benefit (especially regarding oxygenation), these agents must be given via an inhaled route. The misconception that inhaled... read more

 
 
Intra-Abdominal Hypertension – Core Critical Care

 

Intra-Abdominal Hypertension – Core Critical Care

The most popular book at ISICEM meeting. Despite increasing interest in intra-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS) as causes of significant morbidity and mortality among the critically ill,... read more

 
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LATEST CRITICAL CARE PODCASTS
 

The Coagulation Cascade Simplified
Dr. Eric Simms joins us on Rounds to share with us his foolproof and fun way of remembering the dreaded coagulation cascade.

Flight medicine with Tyler Christifulli and Sam Ireland
Part two of our interfacility transfer from Hell. Tyler Christifulli, FP-C, EMT-P and Sam Ireland FP-C, EMT-P show us how they handle GI bleeding, arrhythmias, shock, cardiac arrest, and more, all from the confines of a helicopter.

IBCC chapter & cast: Guillain-Barre Syndrome
Guillain-Barre Syndrome is the most common cause of acute-onset neuromuscular weakness requiring ICU admission. COVID-19 appears to be one trigger of Guillain-Barre Syndrome, so this might be even more common in the coming months.

What Helps?
Antibody treatment may point the way to why some people with COVID-19 get critically ill while others don’t. Antibodies don’t tell the whole story when it comes to the development of critical illness in people with COVID-19. Arturo Casadevall, an expert in antibody treatment of infectious diseases at Johns Hopkins, notes a curious phenomenon.

Tranexamic Acid in Acute GI Bleeding
Effects of a high-dose 24-h infusion of tranexamic acid on death and thromboembolic events in patients with acute gastrointestinal bleeding (HALT-IT): an international randomised, double-blind, placebo-controlled trial.

 
CRITICAL CARE UPCOMING EVENTS
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POPULAR CRITICAL CARE BOOKS
TOP KNIFE: The Art & Craft of Trauma Surgery
TOP KNIFE: The Art & Craft of Trauma Surgery
Deep Medicine: How Artificial Intelligence Can Make Healthcare Human Again
Deep Medicine: How Artificial Intelligence Can Make Healthcare Human Again
Red Book: Report of the Committee on Infectious Diseases
Red Book: Report of the Committee on Infectious Diseases
Genome: The Autobiography of a Species in 23 Chapters
Genome: The Autobiography of a Species in 23 Chapters
Basics of Mechanical Ventilation
Basics of Mechanical Ventilation
Acute Respiratory Distress Syndrome
Acute Respiratory Distress Syndrome
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