In CRITICALLY ILL patients with COVID-19, an initial strategy of therapeutic-dose anticoagulation is not associated with a greater probability of survival to hospital discharge or a greater number of days free of cardiovascular... read more

The latest edition of this handbook is a concise yet comprehensive guide for attending physicians, fellows, residents, and students who cover the ICU. The chapters follow an outline format and are divided by organ system,... read more

In our meta-analysis of RCTs, higher positive end-expiratory pressure (PEEP), compared with lower PEEP, was not associated with mortality in patients without acute respiratory distress syndrome (ARDS) receiving invasive mechanical... read more

Dynamic or hybrid configurations for extracorporeal membrane oxygenation (ECMO) are needed when patient physiology or clinical conditions change. Dynamic configurations included configurations converting from veno-arterial... read more

The Advanced Ventilator Book is a companion to the best-selling The Ventilator Book and is written for clinicians who already have a solid foundation in the basics of mechanical ventilation. It goes beyond the ventilator... read more

Acute respiratory distress syndrome (ARDS) is a clinically heterogenous syndrome, rather than a distinct disease. This heterogeneity at least partially explains the difficulty in studying treatments for these patients and... read more

Melbourne’s second wave of COVID-19 last year, which led to a lockdown lasting more than 100 days, provided us with many lessons about controlling transmission. Some of these are pertinent as New South Wales endures its... read more

Fleisher & Ludwig’s Textbook of Pediatric Emergency Medicine has long been acknowledged as the indispensable comprehensive clinical reference on diagnosing and managing emergent health issues in children. Now,... read more

Among noncritically ill patients with COVID-19 infection, therapeutic anticoagulation with heparin improved the proportion of patients who survived without need for organ support. Therapeutic anticoagulation was associated... read more

Possibly, the future of research and clinical practice is not conceived as a confrontation between Randomized control trial (RCT) and observational studies, but rather as the sum of knowledge between RCTs and its clinical... read more

Evidence supports the use of ketamine for acute pain in a variety of contexts, including as a stand-alone treatment, as an adjunct to opioids, and, to a lesser extent, as an intranasal formulation. Contraindications for acute... read more

This recently released practically oriented book provides an up-to-date overview of all significant aspects of the pathogenesis of sepsis and its management, including within the ICU. Readers will find information on the... read more

Among critically ill adults, compared to control, low molecular weight heparin (LMWH) reduces incidence of deep venous thrombosis (DVT) while UFH and mechanical compressive devices may reduce risk of DVT. LMWH is probably... read more

Continuous positive airway pressure with patient mobilization (including pronation) was effective and safe in patients with ARDS due to COVID-19 managed outside the intensive care unit setting during the pandemic. Of 90 ARDS... read more

Low levels of brain injury markers in blood are associated with good neurological outcome after CA. Incorporating biomarkers into neuroprognostication may help prevent premature withdrawal of life-sustaining therapy. Retrospective... read more