This study aimed to compare the specificity of the metabolic alterations induced by COVID-19 or Influenza A pneumonia (IAP) in acute respiratory distress syndrome (ARDS). Our findings support the concept that ARDS is associated... read more

Who says understanding ventilator modes has to be hard? This book gives you easy to understand information that every RRT, RN, or Resident always wishes they had. Each mode is described in simple language and answers the... read more

COVID-19 can cause liver injury. Mortality, disease severity, and hospital length of stay are increased in COVID-19 patients with hepatopancreatic injury. Forty-five thousand three hundred sixty patients were included in... read more

This book covers the up-to-date advancement of respiratory monitoring in ventilation support as well as detecting the physiological responses to therapeutic interventions to avoid complications. Mechanical ventilation nowadays... read more

This important first study, using multipotent adult progenitor cells in ARDS patients (MUST-ARDS), was a phase 1/2 randomised, blinded, placebo-controlled trial that demonstrated safety and tolerability of intravenous administration... read more

When performing non-invasive ventilation among patients with de novo acute hypoxaemic respiratory failure (AHRF), it is important to avoid excessive tidal volume and lung injury. Although pressure support is needed for some... read more

The novel coronavirus 2019 (COVID-19) has caused a serious global pandemic in just one year. Nearly every country and territory in the world has been affected by the virus. The virulence and infection rate of the virus are... read more

In its most basic sense, the physical exam is a method of inferring the state of health of the internal organs. For two centuries, it has been accomplished through auscultation, inspection, palpation, and percussion. These... read more

In patients presenting with RVF in the ICU (or in situations where the apical echocardiographic view is suboptimal for tricuspid annular assessment), SEATAK can be an alternative to TAPSE. Further research is needed to validate... read more

Many ICU patients with severe sepsis who developed prolonged mental status changes and neurological sequelae showed signs of brain atrophy. Patients with rapidly progressive brain atrophy were more likely to have required... read more

A recent cohort study published in JAMA based on data from 116,507 survivors of hospital-treated sepsis in Germany sheds light on the heavy burden of long-term effects of sepsis, the most severe complication of infections.... read more

In a large cohort of infants at children’s hospitals, noninvasive and invasive ventilation increased significantly from 2010 to 2018. Hospital-level noninvasive ventilation utilization was not associated with a reduction... read more

A fundamental and respected resource book in critical care, The ICU Book, continues to provide the current and practical guidance that have made it the best-selling text in critical care. The text addresses both the medical... read more

COVID-19-induced acute respiratory distress syndrome (ARDS) is associated with prolonged respiratory failure and high mortality, but the mechanistic basis of lung injury remains incompletely understood. Here, we analyzed... read more

Sepsis and acute lung injury (ALI) are linked to mitochondrial dysfunction; however, the underlying mechanism remains elusive. We previously reported that c-Jun N-terminal protein kinase 2 (JNK2) promotes stress-induced mitophagy... read more

Overall, these data demonstrate a proliferation of recovery, follow-up and rehabilitation services for critically ill adults in the past decade across the UK, although service gaps remain suggesting further work is required... read more

Domain adaptation improved performance of a model predicting sepsis-associated vasopressor use during external validation. 40 retrospectively collected features from the electronic medical records of adult ICU patients at... read more

The DDAVP clamp technique has considerably simplified the management of severe hyponatremia. The DDAVP clamp was a substantial step forwards in the management of severe hyponatremia. It eliminated a lot of the variability... read more