Long COVID Associated with Reduced Circulating Serotonin Levels

Post-acute sequelae of COVID-19 (PASC, “Long COVID”) pose a significant global health challenge. The pathophysiology is unknown, and no effective treatments have been found to date. Several hypotheses have been... read more

Tags: coagulopathy, COVID-19, inflammation, serotonin, study, thrombocytopenia, treatment,

Mechanical Ventilation in Patient with Respiratory Failure

This handbook covers the principles of mechanical ventilation, making them easy to understand and apply in clinical settings. Presented in an accessible style and supplemented by a wealth of illustrations and graphs, it includes... read more

Tags: book, education, ICU, mechanical ventilation, pulmonology,

Haloperidol and Delirium: What is Next?

Haloperidol is, by far, the best-studied antipsychotic in ICU, appears to be safe in the dosing range used in these two trials and is easy to administer and titrate. For these reasons, if a clinician chooses to pharmacologically... read more

Tags: antipsychotics, delirium, ICU, mechanical ventilation, sedation, trial,

Levels of Intensive Care vs. In-Hospital Mortality in Patients Hospitalized for Sepsis Stratified by SOFA

Patients hospitalized for sepsis with Sequential Organ Failure Assessment (SOFA) scores greater than or equal to 6 in the ICU or HDU had lower in-hospital mortality than those in the general ward, as did those with SOFA scores... read more

Tags: infection, mortality, sepsis, SOFA,

Sepsis: Definitions, Pathophysiology and the Challenge of Bedside Management

A comprehensive and state-of-the-art resource for clinicians who care for patients with sepsis and research scientist alike. Patients with severe sepsis requiring ICU admission have very high rates of ICU and overall hospital... read more

Tags: book, ICU, research, sepsis, septic shock,

Thrombocytopenia and Platelet Transfusions in ICU Patients

In this international prospective cohort study of acutely admitted adult ICU patients, we found that 43% had thrombocytopenia; 23% at ICU admission and 20% developed it during ICU stay. Patients with thrombocytopenia had... read more

Tags: ICU, mortality, thrombocytopenia, thromboprophylaxis, transfusion,

Tight Blood-Glucose Control without Early Parenteral Nutrition in the ICU

In critically ill patients who were not receiving early parenteral nutrition, tight glucose control did not affect the length of time that ICU care was needed or mortality. Of 9,230 patients who underwent randomization, 4,622... read more

Tags: glucose, hypoglycemia, ICU, insulin, mortality, nutrition,

Uncommon Diseases in the ICU

This book highlights the practical characteristics of uncommon diseases and presents the most relevant features for the management of intensive care units. It does not aim to provide an exhaustive description of uncommon... read more

Tags: book, coronavirus, COVID-19, epidemiology, ICU, treatment,

Enteral Citrulline Supplementation vs. Placebo in Mechanically Ventilated Patients

Among mechanically ventilated ICU patients without sepsis or septic shock, enteral L-citrulline administration did not result in a significant difference in SOFA score on day 7 compared to placebo. Of 120 randomized patients... read more

Tags: ICU, infection, mechanical ventilation, placebo, sepsis, septic shock, study, treatment,

ECLS in Infarct-Related Cardiogenic Shock

In patients with acute myocardial infarction complicated by cardiogenic shock with planned early revascularization, the risk of death from any cause at the 30-day follow-up was not lower among the patients who received ECLS... read more

Tags: bleeding, cardiogenic shock, mortality, stroke, therapy,

COVID-19-associated Sepsis: Incidence and Mortality

In this retrospective cohort study of hospitalized adults, SARS-CoV-2 accounted for approximately 1 in 6 cases of sepsis during the first 33 months of the COVID-19 pandemic. In-hospital mortality rates for SARS-CoV-2–associated... read more

Tags: bacteria, COVID-19, EHR, mortality, sepsis,

Optimal RRT for Critically Ill Patients with Severe AKI

In critically ill patients with severe acute kidney injury (AKI), initiation of continuous renal replacement therapy (CRRT), as compared to intermittent hemodialysis (IHD), was associated with a significant reduction in the... read more

Tags: AKI, CRRT, hemodialysis, IHD, RRT, trial,

ECMO-Extracorporeal Life Support in Adults

Extracorporeal membrane oxygenation (ECMO) has been in clinical use for some 40 years, but it is only in the past decade that its application in the treatment of life-threatening circulatory and respiratory failure has truly... read more

Tags: book, cannulation, ECMO, monitoring, oxygenation,

Revisiting VA-ECMO in Infarct-related Cardiogenic Shock

Despite advances in medical therapies and coronary revascularization, infarct-related cardiogenic shock remains a life-threatening emergency with high death rates. Temporary mechanical circulatory support, including peripheral... read more

Tags: bleeding, cardiogenic shock, ECMO, hemodynamics, ischemia, stroke,

Science and Practice of Pediatric Critical Care Medicine

The field of critical care medicine is in the midst of a dramatic change. Technological and scientific advances during the last decade have resulted in a fundamental change in the way we view disease processes, such as sepsis,...

Therapeutic Hypothermia After Cardiac Arrest

Therapeutic hypothermia has emerged as a very important treatment option for patients with cardiac arrest as it provides significant protection from developing neurologic injury once the patient has been successfully resuscitated....