Delirium Treatment with Haloperidol Not Associated with Higher Risk of QTc-interval Prolongation

Delirium Treatment with Haloperidol Not Associated with Higher Risk of QTc-interval Prolongation

Delirium treatment with haloperidol and/or pipamperone was not associated with a higher risk of QTc-interval prolongation in this naturalistic patient sample but was greater in magnitude and correlated with equipotent dosage... read more

Haloperidol and Delirium: What is Next?

Haloperidol and Delirium: What is Next?

Haloperidol is, by far, the best-studied antipsychotic in ICU, appears to be safe in the dosing range used in these two trials and is easy to administer and titrate. For these reasons, if a clinician chooses to pharmacologically... read more

Antipsychotics to Treat Delirium in Hospitalized Patients Not Including the ICUs

Antipsychotics to Treat Delirium in Hospitalized Patients Not Including the ICUs

No evidence has been found to support or refute the suggestion that antipsychotics shorten the course of delirium in hospitalized patients. Based on the available studies, antipsychotics do not reduce the severity of delirium... read more

Remodeling ICU Care

Remodeling ICU Care

A new study finding that two antipsychotics were no more effective than placebo for delirium in critical illness spurs discussion about alternative methods for managing that care. Neither haloperidol nor ziprasidone — both... read more

Delirium in Critical Illness: Haloperidol vs Ziprasidone?

Delirium in Critical Illness: Haloperidol vs Ziprasidone?

Delirium is defined as an acute disorder of consciousness which can occur in up to 80% of mechanically ventilated ICU patients. This acute cognitive dysfunction is associated with prolonged hospital stay, increased mortality,... read more

No more antipsychotics for delirium? Not so fast!

No more antipsychotics for delirium? Not so fast!

Recently the MINDS-USA trial evaluated the use of haloperidol or ziprasidone for delirium in critical illness. Before jumping into the results of this study, it will help to establish a couple of foundational principles.... read more

Antipsychotic Prescribing Patterns During and After Critical Illness

Antipsychotic Prescribing Patterns During and After Critical Illness

In this study, antipsychotics were used to treat nearly half of all antipsychotic-naïve ICU patients and were prescribed at discharge to 24% of antipsychotic-treated patients. Treatment with an atypical antipsychotic greatly... read more