Citrate Anticoagulation for CRRT

Regional citrate anticoagulation (RCA) is a viable option for liver failure patients. The pro-posed inducible metabolic pathway hypothesis challenges the belief in hepatic dominance over citrate metabolism during RCA-CRRT.... read more

Tags: anticoagulation, coagulation, CRRT, hyperlactatemia, liver failure, RRT, study,

Moderate and Deep Sedation in Clinical Practice

Millions of procedures requiring sedation are performed each year, covering a large array of medical specialties in both inpatient and outpatient settings. This tremendous growth has led to sedation being administered by... read more

Tags: book, education, pharmacology, sedation,

Efficacy of β-Blockers in Decreasing Mortality in Sepsis and Septic Shock Patients

This study suggests that the use of β-blockers in sepsis and septic shock patients is associated with a significant decrease in in-hospital mortality and also associated with better patient outcomes. As β-blockers cause... read more

Tags: hypoperfusion, hypotension, infection, inflammation, mechanical ventilation, norepinephrine, RRT, sepsis, septic shock, treatment,

How to end quiet suffering in the ICU? Identifying and treating hypoactive delirium

The duration of time a person spends in hypoactive delirium predicts higher rates of death, longer length of stay, higher costs of care, and higher rates of acquired dementia in the months and years following critical illness.... read more

Tags: delirium, EEG, ICU, PICS, RASS, sedation,

Clinical Examination Skills in the Adult Critically Ill Patient

This well-illustrated book provides detailed guidance on all aspects of physical examination in patients requiring emergency or intensive care. After an introductory section covering basic principles and the recognition of... read more

Tags: ARDS, book, education, ICU, infection, shock, trauma,

Withholding Early Parenteral Nutrition on 2-year Mortality in Critically Ill Adults

Late-PN did not alter 2-year survival and physical functioning in adult critically ill patients, independent of anticipated nutritional risk. In this prospective follow-up study of the multicenter EPaNIC randomized controlled... read more

Tags: ICU, mortality, nutrition, trial,

Prehospital Treatment of Severely Burned Patients

In the Berlin metropolitan area, paramedics and emergency physicians caring for severely burned patients need to consider long transport times. Current adherence to prehospital treatment recommendations is unsatisfactory.... read more

Tags: burns, intubation, opioids, research, treatment,

Can Clinicians Identify CAP on Ultralow-dose CT?

This study found that clinicians could assess chest ULD-CTs for community-acquired pneumonia (CAP) with high, but not perfect, diagnostic accuracy using an ED radiologist’s assessments as reference standard. Interrater... read more

Tags: CAP, diagnosis, pneumonia, study, tomography, ultrasound,

Ketamine for Treatment-Resistant Depression

This book brings together an international group of clinicians and researchers from a broad swath of inter-related disciplines to offer the most up-to-date information about clinical and preclinical research into ketamine... read more

Tags: book, depression, ketamine, research, sedation, treatment,

Effectiveness of Fludrocortisone and Hydrocortisone vs. Hydrocortisone Alone in Septic Shock

Steroid use in sepsis is controversial. For example, fludrocortisone–hydrocortisone together may improve survival in septic shock, while hydrocortisone alone may not. A recent subgroup analysis of the APROCCHSS trial suggested... read more

Tags: hydrocortisone, sepsis, septic shock, study, trial,

Device Associated Complications in the ICU

Although mortality in the intensive care unit (ICU) has declined over time, ICU associated complications remain common, affecting up to a half of critically ill patients and resulting in increased mortality, longer hospital... read more

Tags: CVC, ECMO, hemodialysis, ICU, tracheostomy,

Emergency and Prophylactic ECMO for Patients Undergoing Valve-in-Valve Transcatheter Aortic Valve Implantation with Small Surgical Bioprosthesis

Mechanical circulatory support (MCS) using veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is widely implemented as a rescue device in transcatheter aortic valve implantation (TAVI). Although prophylactic VA-ECMO... read more

Tags: CPR, ECMO, hemodynamics, ICU, oxygenation, TEE, TTE,

Pediatric Liver Intensive Care

Acute management of children with liver disease and liver transplantation has rapidly evolved over the last two decades due to worldwide availability of complex liver surgery and liver transplantation. This book edited by... read more

Tags: book, hepatology, liver, pediatrics, transplantation,

Outcomes for Mechanically Ventilated Patients with Acute Myocardial Infarction Admitted to Medical vs Cardiac ICUs

In this multicenter, national analysis of ICU admission for critically ill patients with AMI, we found that admission to the Cardiac Intensive Care Unit (CICU) was associated with lower in-hospital mortality than patients... read more

Tags: cardiac arrest, cardiogenic shock, cardiology, ICU, mechanical ventilation, myocardial infarction, triage,

Pressure Support Ventilation During ECMO Support in Patients with ARDS

In the initial phases of veno-venous extracorporeal membrane oxygenation (VV ECMO) support for severe acute respiratory distress syndrome (ARDS), ultraprotective controlled mechanical ventilation (CMV) is typically employed... read more

Tags: ARDS, ECMO, ICU, intubation, mechanical ventilation, oxygenation, study,

Risk Factors for Mortality in Patients with Sepsis or Sepsis-associated Delirium Based on the MIMIC-IV Database

Research on the severity and prognosis of sepsis with or without progressive delirium is relatively insufficient. We constructed a prediction model of the risk factors for 28-day mortality in patients who developed sepsis... read more

Tags: albumin, delirium, ICU, sepsis, septic shock, SOFA, study,

Hospitalizations for Multisystem Inflammatory Syndrome in Children (MIS-C) in US

Multisystem inflammatory syndrome in children (MIS-C) is a rare, serious condition characterized by fever and multiorgan involvement that occurs after SARS-CoV-2 infection. US Centers for Disease Control and Prevention (CDC)... read more

Tags: CDC, COVID-19, diagnosis, infection, inflammation, pediatrics, study,

Expectations of Recovery: ICU Anecdotes

Most of us believe we know our loved ones’ wishes. You may know what your father’s favorite meal is or what he enjoys doing on a Sunday afternoon. But do you know if he would want a feeding tube if he can’t...

Families in the Intensive Care Unit: A Guide to Understanding, Engaging, and Supporting at the Bedside

Written by experts in the field, Families in the Intensive Care Unit: A Guide to Understanding, Engaging and Supporting at the Bedside is a state-of-the-art reference for all clinicians who work with families in the ICU....