Enhancing Early Mortality Prediction for Sepsis-associated ARDS Patients Using Machine Learning

This study utilized the MIMIC-IV, eICU CRD, and NWICU databases to construct and validate a machine learning model, SAFE-Mo, which predicts early mortality in patients with sepsis-associated acute respiratory distress syndrome... read more

Tags: AI, ARDS, research, sepsis, technology,

Severe Trauma and Sepsis: Organ Damage and Tissue Repair

This book discusses recent progress in organ damage and tissue repair following severe trauma and sepsis. In part 1, it introduces the theory and clinical practice in organ damage. In part 2, it covers all the subjects of... read more

Tags: book, education, infection, inflammation, sepsis, trauma,

Restrictive vs. Liberal Transfusion Strategy in Patients with Spontaneous ICH

Red blood cell transfusions are commonly administered to anemic patients with spontaneous intracerebral hemorrhage (ICH); however, the optimal hemoglobin threshold to initiate transfusion is uncertain in this population.... read more

Tags: anemia, brain injury, hematoma, ICH, strategy, TBI, transfusion,

Hemodynamic Monitoring in the ICU

This book describes the pathophysiological significance of the hemodynamic monitoring parameters available to the clinician and their role in providing reliable and reproducible information on the cardiocirculatory status... read more

Tags: book, education, hemodynamics, ICU, monitoring,

Neurally Adjusted Ventilatory Assist Decreases the Requirement of Corticosteroids

This study aimed to evaluate the incidence of bronchopulmonary dysplasia (BPD) and the dosage of corticosteroids in extremely preterm infants with the implementation of neurally adjusted ventilatory assist (NAVA). This is... read more

Tags: corticosteroids, mechanical ventilation, neonates, pediatrics, ventilation,

Impact of Low-Dose Ketamine Infusion on Intracranial Pressure and Hemodynamics in Septic Shock Patients

Adult patients with septic shock, on hemodynamic support, had high-to-normal intracranial pressure (ICP). Low-dose continuous ketamine infusion as an adjunct sedative appeared to have favorable outcomes concerning ICP and... read more

Tags: hemodynamics, ICP, ketamine, mechanical ventilation, sedation, septic shock, TBI, vasopressors, ventilation,

Anticoagulation Management and Outcomes in Critically Ill Patients with Acute Mesenteric Ischemia

This study suggests a significant survival benefit of early full-dose anticoagulation in ICU patients with acute mesenteric ischemia and no difference in hemorrhagic complications. Early full-dose anticoagulation and revascularization... read more

Tags: anticoagulation, hemorrhage, ischemia, mechanical ventilation, study,

Increased Driving Pressure During Assisted Ventilation for Hypoxemic Respiratory Failure Is Associated with Lower ICU Survival

Driving pressure is marker of severity and a possible target for lung protection during controlled ventilation, but its value during assisted ventilation is unknown. Inspiratory holds provide an estimate of driving pressure... read more

Tags: hypoxemia, ICU, mechanical ventilation, study, ventilation, ventilator,

The Role of Neuroimaging in Brain Death Diagnosis

Brain death remains a medically and ethically complex topic, due to its religious and philosophical implications, despite the attempt to “scientificise” what is death and what is not. BD is characterized by a... read more

Tags: brain injury, diagnosis, EEG, guidelines, research, TBI, trauma,

Sepsis Management: PIRO and MODS

This book is unique in approaching multiple organ dysfunction syndrome (MODS) from the perspective of its pathophysiological mechanism, and addressing aspects that are overlooked in most of the available literature. Eminent... read more

Tags: antibiotics, book, infection, MODS, sepsis, treatment,

Airway Management Success in Out-of-hospital Cardiac Arrest Using Different Devices

Although this study found no significant difference in the FPS rates between direct laryngoscopy and video laryngoscopy, the more frequent use of conventional laryngoscopy was associated with a lower FPS rate among anesthetists.... read more

Tags: CPR, ETI, ICU, intubation, laryngoscopy, resuscitation, study,

Altered Lower Brainstem Neurophysiological Response Is Associated with Mortality In Deeply Sedated Critically Ill Patients

Absent cough reflex is associated with mortality in intensive care unit (ICU) patients requiring deep sedation, suggesting that lower brainstem dysfunction contributes to adverse outcomes. We conducted a multicenter observational... read more

Tags: ICU, mortality, sedation, study,

The Influencing Factors of Neonatal Extubation Failure

This study conducted a systematic review and meta-analysis of 22 studies, revealing significant differences in risk factors between the extubation success and failure groups. Subgroup analysis further showed variations in... read more

Tags: extubation, intubation, mechanical ventilation, neonates, pediatrics, research, study,

Handbook of Sepsis

This recently released practically oriented book provides an up-to-date overview of all significant aspects of the pathogenesis of sepsis and its management, including within the ICU. Readers will find information on the... read more

Tags: book, guidelines, ICU, immunotherapy, sepsis, therapy,

TBI Management in the ICU

Despite advances in the management of traumatic brain injury (TBI) in the intensive care unit (ICU), and the implementation of new diagnostic techniques and monitoring modalities, the rate of poor neurological outcomes remains... read more

Tags: diagnostics, ICU, TBI, trauma,

TBI: Quantifying Methodological Uncertainties and Navigating Feasibilities in Monitoring of Cerebral Autoregulation

Traumatic brain injury (TBI) remains a critical medical challenge due to its heterogeneous nature and complex pathophysiological mechanisms. Individualized management of TBI patients, taking advantage of such technologies... read more

Tags: brain injury, ICU, monitoring, TBI, trauma,

Cytokine Storm Syndrome

Cytokine Storm Syndromes, including HLH and MAS, are frequently fatal disorders, particularly if not recognized early and treated during presentation. The genetics of Cytokine Storm Syndromes are being defined with many of... read more

Tags: book, coronavirus, COVID-19, education, infection, research,

Improving Hemodynamics in Vasoplegia Septic Shock with Adjunctive Tocilizumab

In pediatric patients with vasoplegia septic shock, adjunctive tocilizumab is associated with improved hemodynamics, shortened shock duration, and reduced mortality. IL-6 may serve as both a biomarker and therapeutic target... read more

Tags: hemodynamics, hypotension, pediatrics, sepsis, septic shock, study, vasoplegia,

oXiris Treatment Efficacy To Reduce Endotoxin Levels

In this pilot study of patients with CS requiring VA-ECMO, the application of an oXiris did not demonstrate a significant reduction in endotoxin levels at 48 h compared with standard care. While we observed temporal decreases... read more

Tags: cardiogenic shock, cytokine, ECMO, inflammation, resuscitation, study, treatment, trial, vasopressors, weaning,

Endotracheal Intubation Preoxygenation in Resource-limited Settings

Optimal preoxygenation strategies for endotracheal intubation (ETI) in LRS require both protocol adaptation and clinical resourcefulness. An individualized approach using the most feasible combination of techniques should... read more

Tags: ICU, intubation, oxygenation, PEEP, ventilation,

Antibiotic Pharmacokinetic/Pharmacodynamic Considerations in the Critically Ill

This book provides unique insights into the issues that drive modified dosing regimens for antibiotics in the critically ill. Leading international authors provide their commentary alongside a summary of existing evidence...

Evidence-Based Critical Care

This is the premier evidence-based textbook in critical care medicine. The Third Edition features updated and revised chapters, numerous new references, streamlined content, and new chapters on key topics such as the new...