Acute kidney injury (AKI) is a common complication of critical illness and is associated with significant morbidity, mortality, and financial cost. Sepsis is the leading association of acute kidney injury... read more

Most of us believe we know our loved ones’ wishes. You may know what your father’s favorite meal is or what he enjoys doing on a Sunday afternoon. But do you know if he would want a feeding... read more

Effective antimicrobial administration within the first hour of documented hypotension was associated with increased survival to hospital discharge in adult patients with septic shock. Despite a progressive... read more

After adjustment for immortal time bias, Inferior Vena Cava (IVC) filter placement was associated with increased 30-day mortality in patients with venous thromboembolic disease (VTE) and a contraindication... read more

Cellular metabolic abnormalities are responsible for systems and organ failures, so the modern approach of organ dysfunctions now includes prevention or treatment of such disorders. This book is a comprehensive... read more

Worse global longitudinal strain (GLS) (less negative) values are associated with higher mortality in patients with severe sepsis or septic shock, while such association is not valid for left ventricular... read more

This study provides new information regarding functional outcomes and the factors that influence meaningful aspects of functioning in critically ill children. Identifying patients at greatest risk and... read more

This practical guide provides a multidisciplinary, clinically oriented approach to the management of patients in intensive care. The book discusses the complete range of specialties, including cardiology,... read more

This meta-analysis demonstrates that chest radiograph has a low sensitivity and reasonable specificity compared with CT for detecting lung pathology in critically ill patients. The studies also investigating... read more

Researchers have found that a group of viruses that cause severe stomach illness — including the one famous for widespread outbreaks on cruise ships — get transmitted to humans through membrane-cloaked... read more

Effective teamwork is the goal of any workplace. But few settings offer higher stakes than the fast-paced, life-or-death environment of a hospital intensive care unit (ICU). Team collaboration in ICUs... read more

During a 7-year period, those interns randomly assigned to rotate on ID in the first 6 months of their intern year were more likely to become future ID applicants. This supports prior self-reported survey... read more

Written by an international group of experts in the field, Sepsis, Third Edition is a valuable resource that provides the most practical information for clinicians and practitioners who treat this complication... read more

Despite apparent consensus, lack of shared understanding of the rationale for an intervention may lead to divergent practice patterns and failure to implement standardized, evidence-based practice. There... read more

Mortality from sepsis remains high, with at least 270,000 deaths annually in the United States and more than 5 million deaths worldwide. Despite increasing understanding of the pathophysiology of sepsis,... read more

Although delirium and frailty contribute to mortality, the overall impact of delirium on admission appears to be greater at lower levels of frailty. In contrast to the hypothesis that there is a bimodal... read more

Giving plasma to trauma victims during air transport, rather than waiting until arrival at the hospital, saved lives, according to the results of a study that involved patients treated aboard MetroHealth... read more

For specialist nurses on neurocritical care units, accompanying patients for imaging scans and other procedures has a major impact on nurse staffing ratios, reports a study in the Journal of Neuroscience... read more

Surgical site infections are significant contributors to health care–associated infections. Nursing interventions may help decrease the incidence of surgical site infections, particularly in regards... read more

A randomized controlled trial demonstrates that music intervention to prevent delirium among older patients is one of few strategies that provide support in a critical care setting. This study builds on... read more

Any transplant begins with a phone call but on Sunday, the phone in the Cardiff Transplant Unit kept ringing. It was to prove the start of a remarkable few days as specialists at University Hospital of... read more

US regulators have approved the first therapy based on RNA interference (RNAi), a technique that can be used to silence specific genes linked to disease. The drug, “patisiran“, targets a rare... read more

In the primary analysis, limiting the level of sedation provided no significant benefit in reducing incident delirium. However, in a pre-specified subgroup analysis, lighter sedation levels benefitted... read more

In our ICU, patients mobilized on approximately one-third of vasoactive days. Clinicians should anticipate a higher risk of hypotension during mobilization in patients receiving vasoactive therapy, which... read more