Clinical trials conducted by investigator-led research groups are significantly more frequently cited than industry-led trials in critical care medicine. In addition, costs appear to be substantially lower with investigator-led trials.

Support for and expansion of this model of research can ensure that critical care research is clinically relevant and practice changing.

391 randomized clinical trials identified, and 208,154 recruited subjects.

Funding source—industry versus peer review versus mixed—did not impact citation rates.

Comparative effectiveness studies made up 52.5% of the reports and were cited more frequently than studies evaluating novel technologies.

Eligible trials enrolled at least 100 critically ill adults, children, or neonates, evaluated an intervention that was applied during the ICU stay, and reported mortality and/or length of ICU or hospital stay.

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