Ramelteon 8 mg did not prevent postoperative delirium in patients admitted for elective cardiac surgery.

Incident delirium was measured twice daily using the Confusion Assessment Method-ICU.

The safety outcome was coma-free days assessed by the Richmond Agitation-Sedation Scale.

One-hundred twenty participants were enrolled and analysis completed in 117.

Delirium occurred in 22 of 58 patients allocated to placebo versus 19 of 59 allocated to ramelteon.

Delirium duration, as assessed by the number of delirium-free days was also similar in both groups.

Ramelteon 8 mg or matching placebo starting the night prior to surgery and for a maximum of six nights while in the ICU.

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