Overall, quick Sequential Organ Failure Assessment score outperforms systemic inflammatory response syndrome in predicting sepsis outcome, but quick Sequential Organ Failure Assessment score has relative strengths/weaknesses (more specific but less sensitive) compared with systemic inflammatory response syndrome.

We screened 1,340 studies, of which 121 studies (including data for 1,716,017 individuals) were analyzed.

For mortality prediction, the pooled area under the curve was higher for quick Sequential Organ Failure Assessment score.

Quick Sequential Organ Failure Assessment score consistently outperformed systemic inflammatory response syndrome across all subgroup analyses including patient populations (emergency department vs ICU), study design (retrospective vs prospective), and countries (developed vs resource-limited).

The criterion validity of the quick Sequential Organ Failure Assessment score and systemic inflammatory response syndrome criteria were assessed by measuring its predictive validity for primary (mortality) and secondary outcomes in pooled metrics as mentioned.

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