Enrichment reduces heterogeneity and will enhance the sensitivity of future trials. However, enrichment, even when it identifies more homogenous populations, may not be efficient to deploy in trials or clinical practice.

Many researchers are actively pursuing enrichment strategies to reduce heterogeneity to increase the sensitivity of future trials.

Enrichment refers to the use of measurable patient characteristics, known before randomisation, to refine trial populations.

Biomarkers could increase the diagnostic certainty of sepsis, whereas chest radiology training to enhance reliability of interpretation and stabilisation period of mechanical ventilation have been considered to increase the diagnostic certainty of ARDS.

Read More