D-Dimer cutoff levels adjusted for renal dysfunction appear feasible and safe assessing thromboembolic disease in critically ill patients. Furthermore, adjusted D-dimer cutoff levels seem reliable in patients with acute kidney injury (AKI) and “acute on chronic” renal dysfunction.

In patients with estimated glomerular filtration rate less than 60 mL/min/1.73 m2, the false-positive rate can be reduced when estimated glomerular filtration rate–adjusted D-dimer cutoff levels are applied.

A total of 14,477 patients were included in the final analysis, with 467 patients (3.5%) diagnosed with thromboembolic disease.

Renal dysfunction was observed in 1,364 (9.4%) of the total population.

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