There is a dearth of literature addressing interventions to improve implementation of evidence-based practices in acute respiratory distress syndrome (ARDS). Existing interventions to improve clinician knowledge and facilitate application of low tidal volume ventilation and prone positioning may be effective, but supporting studies have significant limitations.

Two authors independently performed study selection and data extraction using a standardized form.

Due to methodologic heterogeneity of included studies, meta-analysis was not feasible; thus, we provided a narrative summary and assessment of the literature.

Eight nonrandomized studies met our eligibility criteria.

Most studies looked at interventions to improve adherence to low tidal volume ventilation.

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