Oxygen therapy and non-invasive ventilation in COVID-19 should be based on pathophysiological changes and a step-by-step approach should be adopted in choosing the right therapeutic strategy for each patient.

Continuous positive airway pressure (CPAP) has been demonstrated to be an effective alternative to invasive mechanical ventilation even for severe acute hypoxic respiratory failure in COVID-19 patients.

Hence, the choice to treat a patient with non-invasive supports should not be viewed as a second choice due to lack of ICU availability, but rather as the best early therapeutic approach in the initial phase of the disease.

Oxygen therapy and mechanical ventilation in patients with COVID-19 and steps to choose the right therapeutic strategy for each patient.

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