Across all ICUs, the rates of primary BSIs progressively fell from 2.11/1000 patient days in FY05 to 0.32/1000 patient days in FY14; an 85.0% decrease (P<0.0001). Secondary BSIs also progressively decreased from 3.56/1000 to 0.66/1000 patient days; an 81.4% decrease (P<0.0001). The decrease of BSI rates remained significant after controlling for the number of blood cultures obtained and patient acuity.

An increased focus on reducing hospital onset infections at the academic medical center during the last 10 years, including multimodal multidisciplinary efforts to prevent central line associated BSIs, pneumonia, Clostridium difficile disease, surgical site infections, and urinary tract infections, was associated with progressive and sustained decreases for both primary and secondary hospital onset BSIs.

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