This review of preclinical applications assesses the potential of the electronic dura mater to deliver electrical and chemical stimulation to targeted areas of the central nervous system for extended periods.

Soft neural interfaces limit chronic central nervous system inflammation and conform to the surface of the brain and spinal cord. In this preclinical review, the ability to stimulate and record from the same device was found to offer a range of clinical applications, especially when neuromodulation therapies need to be applied in poorly accessible regions or when the therapy can be titrated based on neural activity recordings.

Although challenges lie ahead to reach clinical fruition, the unique mechanical properties and integrated modalities of e-dura provide future opportunities to treat or alleviate neurologic deficits.

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