Comparison of two pharmacokinetic–pharmacodynamic models of rocuronium bromide during profound neuromuscular block.

Our findings indicate that using plasma concentrations of rocuronium bromide estimated with either of the two models, combined with a PD model, provides equal model performance when predicting post-tetanic count (PTC).

These promising results may provide an important advance in guiding rocuronium bromide administration when profound NMB in routine clinical practice is desired.

Data from 30 adult patients undergoing elective abdominal or neurosurgical procedures were included.

Post-tetanic count response profiles during rocuronium bromide infusion were successfully characterised using the population PD analysis.

The models showed a good performance for all PTC categories, albeit with a moderate over-prediction of PTC >6.

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