Closed-loop oxygen control improves oxygen administration in patients with moderate-to-severe AHRF treated with HFNO, increasing the percentage of time in the optimal oxygenation range and decreasing the workload of healthcare personnel.

The present study shows that a closed-loop oxygen control system improves oxygen administration in critically ill patients with moderate-to-severe AHRF treated with HFNO by mainly decreasing the time the patient spent above the limits of the clinically set oxygenation targets.

The closed-loop oxygen control was also associated with a lower need for manual oxygen adjustments.

These results may have important implications both at the patient level, as it decreases the risk of deleterious effects of hypoxia and hyperoxia, and at the healthcare system level as it decreases the healthcare personnel workload and it might be potentially associated with a less use of oxygen, making it a useful asset for high oxygen-demand periods such as a pandemic.

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