Multisystem inflammatory syndrome in children (MIS-C) is a rare, serious condition characterized by fever and multiorgan involvement that occurs after SARS-CoV-2 infection.

US Centers for Disease Control and Prevention (CDC) surveillance data demonstrate that cases peaked in January 2021, with more than 200 cases weekly.

Only 117 cases were reported to the CDC with illness onset during 2023, reflecting decreased incidence and likely incomplete reporting.

As the International Classification of Diseases, Version 10 (ICD-10), diagnosis code for MIS-C was validated, administrative databases may complement traditional surveillance efforts.

We describe MIS-C hospitalizations identified in the Pediatric Health Information System (PHIS; Children’s Hospital Association) with admission in 2023 and compare to cases during peak incidence in 2021.

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