Ventilation management may differ between COVID–19 ARDS (COVID–ARDS) patients and patients with pre–COVID ARDS (CLASSIC–ARDS); it is uncertain whether associations of ventilation management with outcomes for CLASSIC–ARDS also exist in COVID–ARDS.

Epidemiology and key ventilation characteristics were different in patients with COVID–ARDS compared to CLASSIC–ARDS, also ΔP was lower in COVID––ARDS patients.

ΔP had an independent association with outcome in both groups, whereas PEEP had an independent association with outcome only in COVID–ARDS patients.

Individual patient data analysis of COVID–ARDS and CLASSIC–ARDS patients in six observational studies of ventilation, four in the COVID–19 pandemic and two pre–pandemic.

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