Fluid boluses and infusions in the early phase of resuscitation from septic shock and sepsis-induced hypotension

pubmed.ncbi.nlm.nih.gov August 22, 2024

Fluid administration is the first line treatment in intensive care unit (ICU) patients with sepsis and septic shock. While fluid boluses administration can be titrated by predicting preload dependency, the amount of other forms of fluids may be more complex to be evaluated.

We conducted a retrospective analysis in a tertiary hospital, to assess the ratio between fluids given as boluses and total administered fluid intake during early phases of ICU stay, and to evaluate the impact of fluid strategy on ICU mortality.

Data related to fluid administration during the first four days of ICU stay were exported from an electronic health records system (ICCA, Philips Healthcare).

Demographic data, severity score, norepinephrine dose at ICU admission, overall fluid balance and the percentage of different fluid components of the overall volume administered were included in a multivariable logistic regression model, evaluating the association with ICU survival.