An early and active UFNET strategy secured by an advanced hemodynamic protocol using dynamic indices of preload dependence had the capacity to control H72 FB in an ICU population of patients with acute circulatory failure, compared to the standard of care.

In this randomized, controlled, open-label, parallel-group, multicenter, proof-of-concept trial, adults receiving vasopressors, CRRT since ≤ 24 h and cardiac output monitoring were randomized (ratio 1:1) to receive during 72 h a UFNET ≥ 100 ml·h−1, adjusted using a functional hemodynamic protocol (intervention), or a UFNET ≤ 25 ml·h−1 (control).

The primary outcome was the cumulative FB at 72 h and was analyzed in patients alive at 72 h and in whom monitoring and CRRT were continuously provided (modified intention-to-treat population [mITT]).

Secondary outcomes were analyzed in the intention-to-treat (ITT) population.

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