This is first study to compare clinical outcomes between patients with E coli, K pneumoniae, K oxytoca, and P mirabilis BSIs receiving early PDAT vs delayed PDAT using DOOR analysis.

Receiving early phenotype-desirable antimicrobial therapy (PDAT) was associated with favorable 30-day clinical outcomes among patients hospitalized with Enterobacterales BSIs.

Starting early PDAT may be important not only for antimicrobial stewardship but also for improving the clinical outcome of affected patients.

In this cohort study with 8,193 adult patients, those receiving early PDAT had a 52.5% probability of a more desirable clinical outcome than patients receiving delayed PDAT.

The observation persisted in the adjusted analysis, as patients receiving early PDAT had a 52.0% probability for a better clinical outcome than patients receiving delayed PDAT.

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