High cDPP3 Predicts Mortality and Need for Organ Support in Cardiogenic Shock

sciencedirect.com January 21, 2025

The present study confirms that circulating dipeptidyl peptidase 3 (cDPP3) and its kinetics are associated with 30-day mortality and the need for organ support in a large and diverse population of CS.

The prognostic value of cDPP3 in patients under MCS warrants further investigations.

In a large and diverse population of cardiogenic shock patients, high initial cDPP3 was associated with higher 30-day mortality, fewer days alive without cardiovascular support, and a greater need for renal replacement therapy and mechanical ventilation.

Although patients with a sustained high cDPP3 had a very poor prognosis, patients with initially high but decreasing cDPP3 at 72 hours had a markedly lower 30-day mortality, comparable with patients with a sustained low cDPP3.