Association Between Early Ondansetron Use and Sepsis Risk in ICU Patients

bmjopen.bmj.com January 28, 2025

In both patients with SOFA <3 or SOFA >3, early ondansetron use was correlated with a reduced risk of sepsis. Patients with early ondansetron use had lower odds of experiencing sepsis than patients without early ondansetron use, which might provide a reference for the management of sepsis in ICU patients.

There were 6,737 patients with early ondansetron use. In total, 1,646 patients suffered sepsis.

According to the data from multivariate cox regression model, compared with participants without early ondansetron use, the risk of sepsis was reduced in participants with early ondansetron use relative to those without HR (HR=0.84, 95% CI: 0.76 to 0.93).

The risk of in-hospital mortality was reduced in those with early ondansetron use (HR=0.63, 95% CI: 0.55 to 0.72).