Pre-ICU Statin Use, AKI and in Hospital Mortality in Sepsis Patients

link.springer.com March 4, 2025

Pre-ICU statin therapy is associated with a lower risk of acute kidney injury (AKI), and improved in-hospital survival among obese patients with sepsis, suggesting its potential role as a protective measure in this high-risk population.

In this study of 8,921 sepsis patients, pre-ICU statin use was associated with significantly improved outcomes.

Univariate analysis showed that statin use reduced the risk of AKI by 69% (OR = 0.31, 95% CI 0.27–0.44, p < 0.001) and decreased in-hospital mortality by 57% (OR = 0.43, 95% CI 0.22–0.54, p < 0.001). This retrospective cohort study leveraged data from the MIMIC-IV database. The study population was stratified into survivors and non-survivors based on in-hospital mortality.