This analysis of two datasets reveals that aspirin usage is associated with an increased risk of acute kidney injury (AKI) in critical patients with chest trauma; however, no significant association was observed between the dose of aspirin and AKI.

Based on our study and the findings from previous research, we recommend the utilization of ketorolac and ibuprofen for effective pain management in critical patients with chest trauma due to their proven efficacy without posing an increased risk of AKI development.

We selected patients admitted to the intensive care unit (ICU) with chest trauma from the Medical Information Mart for Intensive Care III (MIMIC-III) dataset (2001–2012) and the Medical Information Mart for Intensive Care IV (MIMIC-IV) dataset (2013–2019).

Propensity score matching (PSM) was used to match patients receiving NSAIDs with those not receiving treatment.

Logistic regression was employed to assess the association between different types of NSAIDs and AKI in these patients.

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