The multi-physics simulation (CAFe) model represents a significant step forward in the simulation of coronary artery disease (CAD) progression and offers a promising tool for advancing our understanding of the disease.

This multi-physics, multi-scale approach allows for a more comprehensive prediction of disease pathways, potentially leading to targeted interventions that could preempt disease progression in individual patients.

Simulations were conducted to evaluate CAFe’sability to simulate tissue remodeling, modify geometry, and to test the coupling between CFD, ABM, and FEA. A Windows x64-based PC with 128 GB RAM and 20 CPU cores was utilized. FEA, CFD, and growth models were performed using FEBio v2.3.0.

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