This evidence demonstrated that serum mesencephalic astrocyte-derived neurotrophic factor (MANF) is positively associated with scoring criteria and poor prognosis in community-acquired pneumonia (CAP) patients.

Serum MANF may be of considerable clinical value and can be regarded as a diagnostic and prognostic biomarker in CAP.

Of course, more rigorous and uniform studies are required to further analyze the relationship of serum MANF level with CAP, and to explore the practical significances of assisting clinical decisions.

A total of 319 patients confirmed with CAP were enrolled in this prospective cohort study, all of whom were admitted to the Second Affiliated Hospital of Anhui Medical University between November 2021 and December 2022.

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