This observational retrospective cohort study of 325 patients diagnosed with COVID-19 aimed to determine the relationship between troponin levels and disease severity or mortality.

Conducted at Mohammed VI CHU in Oujda from July to November 2021, the study found that age was significantly different between deceased and cured patients, but sex ratio was not.

Patients with admission troponin levels ≤26 ng/L were more often hospitalized in the standard COVID unit (80.6%), while those with levels >26 ng/L were more frequently admitted to the ICU (56.5%) (p<0.001). Troponin levels were strongly associated with survival; 73% of patients with admission troponin ≤26 ng/L survived (p<0.001). Median serum troponin at death was significantly higher (73 ng/L) than in discharged patients (9.6 ng/L). The maximum measured hs-TnI was markedly higher in deceased patients (200 ng/L) compared to survivors (19 ng/L) (p<0.001). The study concludes that troponin may be an indicator of COVID-19 severity and can help identify patients at higher risk of in-hospital mortality, potentially guiding treatment strategies.

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