Traumatic brain injury (TBI) remains a critical medical challenge due to its heterogeneous nature and complex pathophysiological mechanisms.

Individualized management of TBI patients, taking advantage of such technologies like cerebral autoregulation (CA) monitoring, has the potential to improve outcomes by tailoring interventions to the unique physiological responses of each patient. However, a significant barrier to the widespread clinical use of CA-based metrics is the current lack of reliability and standardization in their assessment and interpretation.

This thesis addresses several core aspects of this problem and represents a significant contribution to both the methodological and clinical understanding of monitoring of cerebral autoregulation and derived pressure targets, particularly in traumatic brain injury.

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