Patients with Acute Respiratory Distress Syndrome (ARDS) can be categorized into hyperinflammatory (high inflammation) and hypoinflammatory (low inflammation) phenotypes to help predict outcomes.

This retrospective cohort study aimed to externally validate an existing 18-variable classification model and test whether a simplified 17-variable version (excluding minute ventilation) could maintain the same accuracy while being easier to use in routine clinical practice.

The 18-variable ARDS inflammatory phenotype model is highly generalizable across different hospital databases.

More importantly, dropping minute ventilation to create a simplified 17-variable model does not sacrifice prognostic accuracy, making it a much more practical and feasible tool for real-time risk stratification in the ICU.

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