Approximately 5–17 cases of adrenal crisis (AC) occur per 100 patient years in patients with primary or secondary adrenal insufficiency (AI). The mortality rate is estimated to be between 0.5% and 2%. Norwegian data indicate that overall, 1 in 7 patients with Addison’s disease eventually dies from AC. It is estimated that AC will account for 5500–10,600 excess deaths in the European Union in the next decade. The main triggers for AC include interruption of gluco-corticoid intake, infections, surgery, gastroenteritis, and stress.

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