Our study confirmed an association between higher driving pressure and higher mortality in mechanically ventilated patients with acute respiratory distress syndrome (ARDS). These findings suggest a possible range of driving pressure to be evaluated in clinical trials. Future research is needed to ascertain the benefit of ventilatory strategies targeting driving pressure in patients with acute respiratory distress syndrome. In the meta-analyses of four studies (3,252 patients), higher driving pressure was associated with a significantly higher mortality. Seven studies including five secondary analysis of previous randomized controlled trials and two observational studies (6,062 patients) were eligible for study.

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