The utility of steroids in sepsis has been debated passionately for decades. There is hope that steroids might improve mortality, but also fear that they could increase infectious complications. Practice varies widely. What does the data truly indicate? This belief is based on the first modern RCT of stress-dose steroids in sepsis by Annane et al. 2002. This study randomized 299 patients with severe vasopressor-refractory shock to placebo versus stress-dose steroids.

Read More