Polymyxin B‑immobilised Hemoperfusion and Mortality in Critically Ill Patients with Sepsis/Septic Shock

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polymyxin-b‑immobilised-hemoperfusion-and-mortality-in-critically-ill-patients-with-sepsis-septic-shock

Sepsis and septic shock originate from a dysregulated immune response to pathogens and cause millions of deaths worldwide. Endotoxin, a principal component of the outer membrane of Gram-negative bacteria, is a potent trigger of the immune response and high endotoxin levels correlate with worse clinical outcomes. Circulating endotoxin can be removed by Polymyxin B-immobilised hemoperfusion (PMX-HP). PMX-HP has been widely used in clinical practice, however its benefit is uncertain.

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