The use of the delirium prevention protocol seems to result in improvement of several delirium outcome measures. Prophylactic treatment with low dose haloperidol in critically ill patients with a high risk of delirium likely appears to exert relevant beneficial effects. With the encouraging results of the recent and present studies, we feel that a randomized prospective intervention study in ICU patients with a high risk for delirium using prophylactic haloperidol should be conducted. It should be considered, given the few side-effects of a low dose haloperidol, to also investigate the effect of a higher prophylactic dosage of haloperidol.

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