Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection.

Variability in pathogenesis and complex pathophysiology often delay diagnosis and create significant challenges for clinical studies in this group of critically ill patients.

Mainly for those reasons, there is no therapy approved so far to overcome the underlying immune dysregulation.

This book provides an overview about the state of the art of sepsis diagnostics and potential future therapies.

The authors, all experts in experimental and clinical sepsis research, seek to provide further understanding of the complexities of the immune response as the physiological basis for the development of new therapeutics in sepsis.

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