Effect of Depth of Sedation in Older Patients Undergoing Hip Fracture Repair on Postoperative Delirium

jamanetwork.com December 15, 2019

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In the primary analysis, limiting the level of sedation provided no significant benefit in reducing incident delirium.

However, in a pre-specified subgroup analysis, lighter sedation levels benefitted reducing postoperative delirium for persons with a CCI of 0. Of 200 participants, the mean (SD) age was 82 (8) years, 146 (73%) were women, 194 (97%) were white, and the mean (SD) CCI was 1.5 (1.8).

One hundred participants each were randomized to receive lighter sedation levels or heavier sedation levels.