Mr. Jackson is a 36-year-old man whom you are caring for in the intensive care unit (ICU). Before this hospitalization, he was healthy and took no medications. He has never smoked, and he drinks three or four beers every week. A week ago, a couple of coworkers in his office had respiratory illnesses, and a day later, he started having fever, chills, cough, and generalized weakness. Two nights ago, he presented to the emergency department with confusion and rapidly progressive dyspnea; urgent endotracheal intubation was performed because of acute respiratory failure. Testing for influenza virus A was positive.

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