From a large panel of leukocyte biomarkers, immunosuppression biomarkers were associated with subsequent sepsis in ED patients with suspected acute infection. Between January 2014 and February 2016, we recruited 272, 59 and 75 patients to cohorts 1, 2, and 3, respectively. Of 47 leukocyte biomarkers, 14 were non‑reliable, and 17 did not discriminate between the three cohorts. Discriminant analyses for predicting sepsis within cohort‑1 were undertaken for eight neutrophil (cluster of differentiation antigens. In a multi‑centre cohort study in four EDs and intensive care units (ICUs), we standardised flow‑cytometric leukocyte biomarker measurement and compared patients with suspected acute infection (cohort‑1) with two comparator cohorts.

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