In isolation of other medication, a hemodynamic response to IV acetaminophen has a higher prevalence in critically ill children with cardiac disease than previously thought and justifies controlled studies in the perioperative and critical care setting. The added impact on individual patient hemodynamics and physiologic instability will require further study. Physiologic vital sign data were analyzed in 5-minute intervals starting 60 minutes before through 180 minutes after completion. All patients less than or equal to 18 years old who received IV acetaminophen. Quaternary pediatric cardiovascular ICU between January 1, 2013, and November 13, 2017.

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